Manchester United midfielder Marouane Fellaini had to be substituted after only 23 minutes of Belgium’s thrilling 4-3 victory over Bosnia-Herzegovina.
Fellaini, who has started United’s past three Premier League games, appeared to suffer a knee injury.
Belgium manager Roberto Martinez said that he feared the 29-year-old had suffered ligament damage.
Yannick Carrasco’s goal sealed victory for Belgium, who have already qualified for next year’s World Cup.
Belgium had won Group H but this win meant Bosnia-Herzegovina gave up second place to Greece, who have a chance of reaching the play-offs as one of the best eight runners-up.
They will have to beat Gibraltar on Tuesday and hope that results in other groups go their way.
Belgium were given the lead by Thomas Meunier, only for the hosts to hit back through Haris Medunjanin and Edin Visca.
Chelsea’s Michy Batshuayi and Tottenham’s Jan Vertonghen restored Belgium’s advantage, only for Dario Dumic to pull Bosnia-Herzegovina level in the 82nd minute.
But, a minute later, Carrasco gave Belgium the points.